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Adv Virus Res. 2019;103:71-133. doi: 10.1016/bs.aivir.2018.10.001. Epub 2018 Dec 5.

Eukaryotic Circular Rep-Encoding Single-Stranded DNA (CRESS DNA) Viruses: Ubiquitous Viruses With Small Genomes and a Diverse Host Range.

Author information

1
Department of Ecology, Evolution and Natural Resources, Rutgers, the State University of New Jersey, New Brunswick, NJ, United States.
2
College of Marine Science, University of South Florida, Saint Petersburg, FL, United States.
3
Department of Ecology, Evolution and Natural Resources, Rutgers, the State University of New Jersey, New Brunswick, NJ, United States. Electronic address: duffy@sebs.rutgers.edu.

Abstract

While single-stranded DNA (ssDNA) was once thought to be a relatively rare genomic architecture for viruses, modern metagenomics sequencing has revealed circular ssDNA viruses in most environments and in association with diverse hosts. In particular, circular ssDNA viruses encoding a homologous replication-associated protein (Rep) have been identified in the majority of eukaryotic supergroups, generating interest in the ecological effects and evolutionary history of circular Rep-encoding ssDNA viruses (CRESS DNA) viruses. This review surveys the explosion of sequence diversity and expansion of eukaryotic CRESS DNA taxonomic groups over the last decade, highlights similarities between the well-studied geminiviruses and circoviruses with newly identified groups known only through their genome sequences, discusses the ecology and evolution of eukaryotic CRESS DNA viruses, and speculates on future research horizons.

KEYWORDS:

Bacilladnavirus; CRESS DNA virus; Circovirus; Geminivirus; Genomovirus; Nanovirus; Single-stranded DNA; Smacovirus

PMID:
30635078
DOI:
10.1016/bs.aivir.2018.10.001
[Indexed for MEDLINE]

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