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Nutrients. 2019 Jan 9;11(1). pii: E122. doi: 10.3390/nu11010122.

Lactofermented Annurca Apple Puree as a Functional Food Indicated for the Control of Plasma Lipid and Oxidative Amine Levels: Results from a Randomised Clinical Trial.

Author information

1
Department of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy. giancarlo.tenore@unina.it.
2
Department of Internal Medicine, Hospital Cardarelli, Via Antonio Cardarelli, 80131 Naples, Italy. domcarus@gmail.com.
3
Coop. Samnium Medica, Viale C. Colombo, 18, 82037 Benevento, Italy. giusbuon@tin.it.
4
Department of Internal Medicine, Hospital Cardarelli, Via Antonio Cardarelli, 80131 Naples, Italy. maridav@gmail.com.
5
Department of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy. rociamp@unina.it.
6
Department of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy. marmais@unina.it.
7
Department of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy. conschi@unina.it.
8
UCCP (Unità Complessa Cure Primarie), Via Manzoni, San Giorgio del Sannio, 82100 Benevento, Italy. brubocch@email.it.
9
Department of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy. enov@unina.it.

Abstract

Atherosclerotic cardiovascular diseases are preferential targets of healthy diet and preventive medicine partially through strategies to improve lipid profile and counteract oxidative metabolites. Ninety individuals with cardiovascular disease (CVD) risk factors were randomized (1:1:1 ratio) to three arms, according to a four-week run-in, eight-week intervention, and four-week follow up study, testing the effects of a lactofermented Annurca apple puree (lfAAP), compared to unfermented apple puree (AAP) or probiotic alone (LAB) on plasma lipid profile and trimethylamine-N-oxide (TMAO) levels. By comparing the treatments, data indicated for the subjects tested with lfAAP a higher variation of the following serum parameters, in respect to the other treatment groups: high density lipoprotein cholesterol (HDL-C), +61.8% (p = 0.0095); and TMAO levels, -63.1% (p = 0.0042). The present study would suggest lfAAP as an effective functional food for beneficial control of plasma HDL-C and TMAO levels.

KEYWORDS:

Annurca apple puree; Lactobacillus; fermentation; functional food; plasma lipids; trimethylamine-N-oxide

PMID:
30634393
PMCID:
PMC6356833
DOI:
10.3390/nu11010122
[Indexed for MEDLINE]
Free PMC Article

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