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Hum Pathol. 2019 Jan 8. pii: S0046-8177(19)30003-6. doi: 10.1016/j.humpath.2019.01.001. [Epub ahead of print]

GATA6: a new predictor for prognosis in ovarian Cancer.

Author information

1
Department of Oncology, Tangdu Hospital, the Fourth Military Medical University, Xi'an, Shaanxi, China, 710038; Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA,TX 77030.
2
Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA,TX 77030.
3
Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA,TX 77030; Department of Pathology, Cancer Hospital and Tianjin Medical University, Tianjin, China, 300060.
4
Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA,TX 77030; Department of Pathology, Xijing Hospital, the Fourth Military Medical University, Xi'an, Shaanxi, China, 710032.
5
Department of Statistics, Fudan University, Shanghai, China,200433.
6
Department of Oncology, Tangdu Hospital, the Fourth Military Medical University, Xi'an, Shaanxi, China, 710038. Electronic address: cnxazhl@163.com.
7
Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA,TX 77030. Electronic address: jliu@mdanderson.org.

Abstract

Ovarian cancer (OC) is the main cause of gynecological cancer-associated mortality. Improving the diagnosis is important for guiding clinical treatment. The present study aimed to investigate the relationship between expression of GATA6, a stem cell factor, and its prognosis in OC. In total, 521 OC cases were included. Immunohistochemistry analysis demonstrated that GATA6 was expressed in both high grade serous carcinoma as well as non-serous tumors. High grade serous carcinoma showed a higher percentage of GATA6 positive staining. Positive staining of GATA6 showed worse overall survival (OS) in all ovarian cancers or serous and non-serous carcinoma individually. GATA6 was revealed as an independent risk factor for prognosis by multivariate Cox analysis. In all, GATA6 may present as a novel marker for poor prognosis in OC.

KEYWORDS:

GATA6; Ovarian Cancer; Prognosis; Stem Cell and Lineage Differentiation Factor

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