Format

Send to

Choose Destination
Leuk Lymphoma. 2019 Jan 11:1-9. doi: 10.1080/10428194.2018.1551536. [Epub ahead of print]

Genetic polymorphisms in genes of class switch recombination and multiple myeloma risk and survival: an IMMEnSE study.

Author information

1
a Department of Biology , University of Pisa , Pisa , Italy.
2
b Genomic Epidemiology Group, German Cancer Research Center (DKFZ) , Heidelberg , Germany.
3
c Hematology Department , Teaching Hospital No 1 , Rzeszów , Poland.
4
d Department of Hematology , Jagiellonian University Medical College , Cracow , Poland.
5
e Lymphoma Department , Centre of Oncology-Institute of Maria Skłodowska-Curie , Warsaw , Poland.
6
f Department of Internal Medicine V , Heidelberg University Hospital , Heidelberg , Germany.
7
g Max-Eder Research Group Experimental Therapies for Hematologic Malignancies, German Cancer Research Center (DKFZ) , Heidelberg , Germany.
8
h Cancer Prevention and Control Program, Catalan Institute of Oncology (ICO), IDIBELL, CIBERESP and Department of Clinical Sciences, Faculty of Medicine , University of Barcelona , Barcelona , Spain.
9
i Molecular Biology Laboratory, Section of Multiple Myeloma, Department of Internal Medicine V , Heidelberg University Hospital , Heidelberg , Germany.
10
j Department of Internal and Occupational Diseases, Hypertension and Clinical Oncology , Wroclaw Medical University , Wroclaw , Poland.
11
k PTS Granada , Genomic Oncology Area, GENYO. Centre for Genomics and Oncological Research: Pfizer / University of Granada / Andalusian Regional Government , Granada , Spain.
12
l Monoclonal Gammopathies Unit, University Hospital Virgen de las Nieves , Granada , Spain.
13
m Pharmacogenetics Unit. Instituto de Investigación Biosanitaria de Granada (Ibs. Granada) , Hospitales Universitarios de Granada / Universidad de Granada , Granada , Spain.
14
n Department of Intrenal Medicine , Semmelweis University , Budapest , Hungary.
15
o Department of Haematology , Copernicus Town Hospital of Torun , Torun , Poland.
16
p Life and Health Sciences Research Institute (ICVS), School of Health Sciences , University of Minho , Braga , Portugal.
17
q INSERM U900 , Paris , France.
18
r Institut Curie , Paris , France.
19
s Mines ParisTech , Fontainebleau , France.
20
t PSL University , Paris , France.
21
u Department of Hematology , Copenhagen University Hospital , Rigshospitalet , Denmark.
22
v National Research Centre for the Working Environment , Denmark.
23
w Department of Hematology , University Hospital , Bydgoszcz , Poland.
24
x Department of Haematology , Military Institute of Medicine , Warsaw , Poland.
25
y Hematology Unit, Department of Clinical and Experimental Medicine , University of Pisa , Pisa , Italy.
26
z Department of Hematology, Copernicus Memorial Hospital , Medical University of Lodz , Lodz , Poland.
27
aa Division of Clinical Epidemiology and Aging Research , German Cancer Research Center (DKFZ) , Heidelberg , Germany.
28
ab Network Aging Research (NAR) , University of Heidelberg , Heidelberg , Germany.
29
ac Cancer Research Center of Lyon, INSERM 1052/CNRS 5286 , University of Lyon , Lyon , France.
30
ad Hospital 12 de Octubre , Complutense University, CNIO, CIBERONC , Madrid , Spain.
31
ae Department of Hematology , University Hospital of Salamanca , Salamanca , Spain.
32
af National Center for Tumor Diseases (NCT) , Heidelberg , Germany.
33
ag Division of Preventive Oncology , National Center for Tumor Diseases (NCT) German Cancer Research Center (DKFZ) , Heidelberg , Germany.
34
ah German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ) , Heidelberg , Germany.
35
ai Department of Hematology , Institute of Hematology and Transfusion Medicine , Warsaw , Poland.
36
aj ICVS/3B's - PT Government Associate Laboratory , Braga/Guimarães , Portugal.
37
ak Barretos Cancer Hospital , Molecular Oncology Research Center , S. Paulo , Brazil.
38
al Department of Hematology , Holy Cross Oncology Center , Kielce , Poland.
39
am Department of Clinical Immunology , Copenhagen University Hospital , Rigshospitalet, Copenhagen , Denmark.
40
an Department of Hematology and Bone Marrow Transplantation , Medical University of Silesia , Katowice , Poland.
41
ao Department of Hematology , University Hospital Morales Meseguer, IMIB , Murcia , Spain.
42
ap Department of Clinical Immunology , Odense University Hospital , Odense , Denmark.
43
aq Department of Hematology , St. John's Cancer Center , Lublin , Poland.
44
ar Department of Experimental Hematooncology , Medical University of Lublin , Lublin , Poland.
45
as Department of Hematology , Sea Hospital , Gdynia , Poland.
46
at IRS-Center Sønderjylland , Aabenraa , Denmark.
47
au Institute of Molecular Biology, University of Southern Denmark , Odense , Denmark.
48
av Department of Haematology , University Hospital of Cracow , Cracow , Poland.

Abstract

Genetic variants in genes acting during the maturation process of immature B-cell to differentiated plasma cell could influence the risk of developing multiple myeloma (MM). During B-cell maturation, several programmed genetic rearrangements occur to increase the variation of the immunoglobulin chains. Class switch recombination (CSR) is one of the most important among these mechanisms. Germline polymorphisms altering even subtly this process could play a role in the etiology and outcome of MM. We performed an association study of 30 genetic variants in the key CSR genes, using 2632 MM patients and 2848 controls from the International Multiple Myeloma rESEarch (IMMEnSE) consortium, the Heidelberg MM Group and the ESTHER cohort. We found an association between LIG4-rs1555902 and decreased MM risk, which approached statistical significance, as well as significant associations between AICDA-rs3794318 and better outcome. Our results add to our knowledge on the genetic component of MM risk and survival.

KEYWORDS:

Multiple myeloma; class switch recombination; genetic polymorphisms; overall survival; progression-free survival; susceptibility

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center