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Tissue Eng Part C Methods. 2019 Feb;25(2):71-81. doi: 10.1089/ten.TEC.2018.0336.

Microwell Scaffolds Using Collagen-IV and Laminin-111 Lead to Improved Insulin Secretion of Human Islets.

Author information

1
1 Department of Developmental BioEngineering, Faculty of Science and Technology, Technical Medical Centre, University of Twente, Enschede, The Netherlands.
2
2 Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands.
3
3 Hubrecht Institute, Utrecht, The Netherlands.
4
4 Bioinspired Molecular Engineering Laboratory and Molecular Nanofabrication Group, MESA+ Institute for Nanotechnology, University of Twente, Enschede, The Netherlands.
5
5 Department of Complex Tissue Regeneration, MERLN Institute for Technology Inspired Regenerative Medicine, Maastricht University, Maastricht, The Netherlands.

Abstract

This research deals with finding a proper bioengineering strategy to improve the outcome of islets transplantation for treatment of type 1 diabetes. It is focused on the mimicking of islet extracellular matrix niche in microwell islet delivery devices to improve their endocrine function.

KEYWORDS:

ECM; insulin secretion; islet function; microwell scaffolds; type 1 diabetes

PMID:
30632461
DOI:
10.1089/ten.TEC.2018.0336

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