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Chem Asian J. 2019 Mar 15;14(6):859-863. doi: 10.1002/asia.201801606. Epub 2019 Jan 11.

Fluorescent Light-up Probe for the Detection of Protein Aggregates.

Author information

1
Department of chemistry and QOPNA, University of Aveiro, Campus of Santiago, Aveiro, Portugal.
2
Department of Medical Sciences and Institute of Biomedicine, IBiMED, University of Aveiro, Agras do Crasto, Aveiro, Portugal.
3
Department of chemistry and CICECO, University of Aveiro, Campus of Santiago, Aveiro, Portugal.

Abstract

A fluorescent dye was decorated with water-soluble pyridinium groups in order to be applied in the detection of cyclodextrins or DNA. The dye displays an enhancement of its emission intensity when the internal rotations are restricted due to the formation of an inclusion complex with cyclodextrins or upon interaction with DNA. In vivo, the fluorescent probe can stain protein aggregates with a selectivity comparable to the widely used Proteostat®.

KEYWORDS:

DNA; aggregation-induced emission enhancement; cyclodextrins; fluorescent probes; protein aggregates

PMID:
30632287
DOI:
10.1002/asia.201801606
[Indexed for MEDLINE]

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