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Andrologia. 2019 May;51(4):e13226. doi: 10.1111/and.13226. Epub 2019 Jan 10.

The effectiveness of Korean herbal medicine in infertile men with poor semen quality: A prospective observational pilot study.

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Department of Korean Obstetrics and Gynecology, Conmaul Hospital of Korean Medicine, Seoul, Korea.
Research institute of Korean Medicine, College of Korean Medicine, Dongguk University, Gyeonggi-do, Korea.
Department of Clinical Korean Medicine, College of Korean Medicine, Kyung Hee University, Seoul, Korea.
Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Yusung-gu, Daejeon, Korea.


We examined the effects and safety of Korean herbal medicine (MYOMI-14) to treat infertile men with low semen quality. This study included 17 patients who received MYOMI-14 for 10 weeks. The primary outcomes were the mean differences between sperm test values. The secondary outcomes were changes in the Fertility Quality of Life and the difference in skin temperature between the thigh and scrotum. Adverse events were also monitored. The average values of sperm concentration, sperm progressive motility and total motile sperm count significantly improved after MYOMI-14 treatment (36.2%, 51.7% and 55.5%, respectively; p < 0.05). The core Fertility Quality of Life and the difference in skin temperature between the thigh and scrotum did not change significantly. No adverse events were observed. MYOMI-14 improved the semen quality of infertile men without adverse effects. Additional studies in a larger population and longer prospective randomised clinical trials are needed to confirm these results.


male infertility; semen analysis; traditional Korean medicine


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