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Front Immunol. 2018 Dec 13;9:2550. doi: 10.3389/fimmu.2018.02550. eCollection 2018.

Humanized Mice Are Instrumental to the Study of Plasmodium falciparum Infection.

Author information

1
Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.
2
Biomedical parasitology Unit, Institute Pasteur, Paris, France.
3
Department of Global Health, College of Public Health, University of South Florida, Tampa, FL, United States.
4
Institute of Science, Nirma University, Ahmedabad, India.
5
Department of Pediatrics, Pathology and Cell Biology, University of South Florida, Tampa, FL, United States.
6
Zydus Research Centre, Ahmedabad, India.
7
Department of Basic and Applied Sciences, School of Engineering, GD Goenka University, Gurgaon, India.

Abstract

Research using humanized mice has advanced our knowledge and understanding of human haematopoiesis, non-adaptive and adaptive immunity, autoimmunity, infectious disease, cancer biology, and regenerative medicine. Challenges posed by the human-malaria parasite Plasmodium falciparum include its complex life cycle, the evolution of drug resistance against anti-malarials, poor diagnosis, and a lack of effective vaccines. Advancements in genetically engineered and immunodeficient mouse strains, have allowed for studies of the asexual blood stage, exoerythrocytic stage and the transition from liver-to-blood stage infection, in a single vertebrate host. This review discusses the process of "humanization" of various immunodeficient/transgenic strains and their contribution to translational biomedical research. Our work reviews the strategies employed to overcome the remaining-limitations of the developed human-mouse chimera(s).

KEYWORDS:

FRG mice; NSG mice; TK/NOG mice; clodronate loaded liposomes; huHep; huRBCs; humanized/chimeric mice; malaria

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