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Perfusion. 2019 Jan 10:267659118822945. doi: 10.1177/0267659118822945. [Epub ahead of print]

Falsely low activated clotting time measured in a patient with sickle cell trait.

Author information

1
Department of Perfusion, Great Ormond Street Hospital for Children, London, UK.

Abstract

Sickle cell anaemia results from homozygosity of an A-T point mutation leading to a substitution of glutamic acid for valine at point 6 of the β-globin gene. A person with sickle cell trait inherits one normal and one mutated allele. Patients with sickle cell anaemia, and to a lesser extent sickle cell trait, have a wide spectrum of haemostatic abnormalities. Here we describe the problems faced in obtaining an accurate activated clotting time measurement, in a patient with sickle cell trait, prior to commencement of cardiopulmonary bypass for decannulation of Berlin Heart.

KEYWORDS:

cardiopulmonary bypass; sickle cell

PMID:
30628549
DOI:
10.1177/0267659118822945

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