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Eur J Orthop Surg Traumatol. 2019 May;29(4):747-757. doi: 10.1007/s00590-019-02366-x. Epub 2019 Jan 9.

Use of stem cells and growth factors in rotator cuff tendon repair.

Author information

1
Barnet General Hospital, Royal Free NHS Foundation Trust, London, UK.
2
Royal Derby Hospital, Derby Teaching Hospitals, Derby, UK. Georgios.konstantopoulos@nhs.net.
3
Shoulder Unit, Barnet General Hospital, Royal Free NHS Foundation Trust, London, UK.
4
Writtington Hospital, Writtington, UK.

Abstract

The management of rotator cuff tears continues to prove challenging for orthopaedic surgeons. Such tears affect most age groups and can lead to significant morbidity in patients. The aetiology of these tears is likely to be multifactorial; however, an understanding of the mechanisms involved is still under review. Despite advancements in surgical operative techniques and the materials used, post-operative recurrence rates after surgical repair remain high. A growing area of research surrounds biological adjuncts used to improve the healing potential of the repaired tissues. This review of recent publications focuses on the strengths and limitations of using stem cells and growth factors in rotator cuff repair.

KEYWORDS:

Growth factors; Mesenchymal stem cells; Rotator cuff tears

PMID:
30627922
DOI:
10.1007/s00590-019-02366-x
[Indexed for MEDLINE]

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