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Neuropsychopharmacology. 2019 Jan 9. doi: 10.1038/s41386-018-0311-6. [Epub ahead of print]

Oxytocin modulates hippocampal perfusion in people at clinical high risk for psychosis.

Author information

1
Early Psychosis: Interventions & Clinical-detection (EPIC) Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
2
Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
3
National Institute for Health Research (NIHR) Biomedical Research Centre (BRC), South London and Maudsley NHS Foundation Trust, London, UK.
4
Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
5
Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
6
Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
7
Tower Hamlets Early Detection Service (THEDS), East London NHS Foundation Trust, London, UK.
8
Department of Psychology, University of Roehampton, London, UK.
9
Institute of Pharmaceutical Science, King's College London, London, UK.
10
Outreach And Support in South London (OASIS) Service, South London and Maudsley NHS Foundation Trust, London, UK.
11
Early Psychosis: Interventions & Clinical-detection (EPIC) Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. paolo.fusar-poli@kcl.ac.uk.
12
National Institute for Health Research (NIHR) Biomedical Research Centre (BRC), South London and Maudsley NHS Foundation Trust, London, UK. paolo.fusar-poli@kcl.ac.uk.
13
Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy. paolo.fusar-poli@kcl.ac.uk.
14
Outreach And Support in South London (OASIS) Service, South London and Maudsley NHS Foundation Trust, London, UK. paolo.fusar-poli@kcl.ac.uk.

Abstract

Preclinical and human studies suggest that hippocampal dysfunction is a key factor in the onset of psychosis. People at Clinical High Risk for psychosis (CHR-P) present with a clinical syndrome that can include social withdrawal and have a 20-35% risk of developing psychosis in the next 2 years. Recent research shows that resting hippocampal blood flow is altered in CHR-P individuals and predicts adverse clinical outcomes, such as non-remission/transition to frank psychosis. Previous work in healthy males indicates that a single dose of intranasal oxytocin has positive effects on social function and marked effects on resting hippocampal blood flow. The present study examined the effects of intranasal oxytocin on hippocampal blood flow in CHR-P individuals. In a double-blind, placebo-controlled, crossover design, 30 CHR-P males were studied using pseudo-continuous Arterial Spin Labelling on 2 occasions, once after 40IU intranasal oxytocin and once after placebo. The effects of oxytocin on left hippocampal blood flow were examined in a region-of-interest analysis of data acquired at 22-28 and at 30-36 minutes post-intranasal administration. Relative to placebo, administration of oxytocin was associated with increased hippocampal blood flow at both time points (p = .0056; p = .034), although the effect at the second did not survive adjustment for the effect of global blood flow. These data indicate that oxytocin can modulate hippocampal function in CHR-P individuals and therefore merits further investigation as a candidate novel treatment for this group.

PMID:
30626906
DOI:
10.1038/s41386-018-0311-6

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