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J Cell Physiol. 2019 Jan 9. doi: 10.1002/jcp.28077. [Epub ahead of print]

Human unrestricted somatic stem cells ameliorate sepsis-related acute lung injury in mice.

Author information

1
Department of Tissue Engineering and Applied Cell Sciences, Faculty of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
2
Hematology and Cell Therapy Department, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
3
Department of Stem Cell Biology, Stem Cell Technology Research Center, Tehran, Iran.
4
Stem Cell and Tissue Engineering Research Center, Shahroud University of Medical Sciences, Shahroud, Iran.
5
Department of Medical Biotechnology, Tabriz University of Medical Sciences, Faculty of Advanced Medical Sciences, Tabriz, Iran.
6
Department of Clinical Pathology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
7
Department of Pathology, School of Veterinary Medicine, Shahrekord University, Shahrekord, Iran.
8
Pediatric Stem Cell Transplant Department, Children's Medical center, Tehran University of Medical Sciences, Tehran, Iran.

Abstract

Sepsis and related disorders, especially acute lung injury (ALI), are the most challenging life-threatening diseases in the hospital intensive care unit. Complex pathophysiology, unbalanced immune condition, and high rate of mortality complicate the treatment of sepsis. Recently, cell therapy has been introduced as a promising option to recover the sepsis symptoms. The aim of this study was to investigate the therapeutic potential of human unrestricted somatic stem cells (USSCs) isolated from human umbilical cord blood in the mouse model of ALI. USSCs significantly enhanced the survival rate of mice suffering from ALI and suppressed concentrations of proinflammatory mediators TNF-α, and interleukin (IL)-6, and the level of anti-inflammatory cytokine IL-10. ALI mice injected by USSCs showed notable reduction in lung and liver injury, pulmonary edema, and hepatic enzymes, compared with the control group. These results determined the in vivo immunomodulatory effect of USSCs for recovery of immune balance and reduction of tissue injury in the mouse model of ALI. Therefore, USSCs can be a suitable therapeutic approach to manage sepsis disease through the anti-inflammatory potential.

KEYWORDS:

acute lung injury; cell therapy; inflammation; umbilical cord; unrestricted somatic stem cells

PMID:
30624762
DOI:
10.1002/jcp.28077

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