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Med Sci (Paris). 2018 Dec;34(12):1047-1055. doi: 10.1051/medsci/2018295. Epub 2019 Jan 9.

[On the road to deciphering the tubulin code: focus on acetylation and detyrosination].

[Article in French]

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Régulation et pharmacologie du cytosquelette, Institut pour l'avancée des biosciences, Université Grenoble Alpes ; Inserm U 1209 ; CNRS 5309, Allée des Alpes, 38700 La Tronche, France.


Microtubules are cytoskeletal fibers formed by the assembly of α- and β-tubulin heterodimers. They contribute to cell morphology, mobility and polarity, as well as to cellular transport processes and cell division. The microtubular network constantly adapts to cellular needs and may be composed of very dynamic or more stable microtubules. To regulate their diverse functions in a spatio-temporal manner, microtubules are subjected to numerous reversible post-translational modifications, which generate the "tubulin code". This review focuses on two modifications characteristic of stable microtubules - acetylation and detyrosination of α-tubulin - and their deregulation in certain pathologies.


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