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Med Sci (Paris). 2018 Dec;34(12):1063-1070. doi: 10.1051/medsci/2018296. Epub 2019 Jan 9.

[Variations on the theme of podosomes, context matters].

[Article in French]

Author information

1
Centre de recherche cardio-thoracique de Bordeaux (Inserm U1045), Université de Bordeaux, Bordeaux Cedex, F-33076 France.
2
Department of chemistry and biotechnology, division of gene technology, Tallinn University of Technology, 12618 Tallinn, Estonie.

Abstract

Podosomes are actin-based microdomains connecting the cell with its extracellular matrix. Contractile actin-myosin cables assemble them into a network that constitutes a versatile cellular superstructure. Discovered and extensively described in in vitro conditions, podosomes now appear as major actors of specific physiological processes. They share common characteristics but their morphology and their effect on cell functioning can only be apprehended in specific cellular contexts. We focus here on three cellular processes involving podosomes and discuss their properties in context.

PMID:
30623771
DOI:
10.1051/medsci/2018296

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