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Med Sci (Paris). 2018 Dec;34(12):1116-1122. doi: 10.1051/medsci/2018290. Epub 2019 Jan 9.

[From genome-wide association studies (gwas) to genome-wide polygenic scores (GPS)].

[Article in French]

Author information

1
UMR 7268 ADÉS, Aix-Marseille, Université/EFS/CNRS ; CoReBio PACA, case 901, Parc scientifique de Luminy, 13288 Marseille Cedex 09, France.

Abstract

The accumulation of extensive repositories linking phenotypic and genetic information, together with new computation methods, makes it possible to derive polygenic scores for susceptibility to common diseases that turn out to have strong predictive power. These will be clinically useful to identify individuals at high risk who may be eligible for protective interventions.

PMID:
30623770
DOI:
10.1051/medsci/2018290

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