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Med Sci (Paris). 2018 Dec;34(12):1079-1086. doi: 10.1051/medsci/2018298. Epub 2019 Jan 9.

[Breast cancer, obesity and adipose tissue: a high-risk combination].

[Article in French]

Author information

1
Institut de pharmacologie et de biologie structurale, CNRS/université de Toulouse UMR 5089, 205, route de Narbonne, BP 64182, F-31077 Toulouse, France.
2
Institut de pharmacologie et de biologie structurale, CNRS/université de Toulouse UMR 5089, 205, route de Narbonne, BP 64182, F-31077 Toulouse, France - Département de chirurgie, CHU-Toulouse, Institut universitaire du cancer de Toulouse-Oncopole, 1, avenue Irène Joliot-Curie, 31059 Toulouse Cedex 9, France.

Abstract

Obesity increases the occurrence of post-menopausal breast cancer and negatively affects prognosis independently of menopausal status. After summarizing the available epidemiological data concerning these associations, we will show that a deleterious crosstalk is established during tumor progression between cancer cells and the surrounding mammary adipose tissue (MAT). In obesity, the chronic sub-inflammatory state of MAT could amplify the negative effect of this crosstalk although other mechanisms also warrant further study. Finally, we will discuss the efficiency of weight loss in both primary prevention and recurrence, a strategy that could be more complex that initially thought.

PMID:
30623763
DOI:
10.1051/medsci/2018298

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