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J Immunol Res. 2018 Dec 6;2018:6872621. doi: 10.1155/2018/6872621. eCollection 2018.

The Role of Zinc and Zinc Homeostasis in Macrophage Function.

Author information

1
The First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China.

Abstract

Zinc has long been recognized as an essential trace element, playing roles in the growth and development of all living organisms. In recent decades, zinc homeostasis was also found to be important for the innate immune system, especially for maintaining the function of macrophages. It is now generally accepted that dysregulated zinc homeostasis in macrophages causes impaired phagocytosis and an abnormal inflammatory response. However, many questions remain with respect to the mechanisms that underlie these processes, particularly at the cellular and molecular levels. Here, we review our current understanding of the roles that zinc and zinc transporters play in regulating macrophage function.

PMID:
30622979
PMCID:
PMC6304900
DOI:
10.1155/2018/6872621
[Indexed for MEDLINE]
Free PMC Article

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