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EMBO Rep. 2019 Jan 8. pii: e46612. doi: 10.15252/embr.201846612. [Epub ahead of print]

The long non-coding RNA LINC00941 and SPRR5 are novel regulators of human epidermal homeostasis.

Author information

1
Institute of Biochemistry, Genetics and Microbiology, University of Regensburg, Regensburg, Germany.
2
Statistical Bioinformatics Department, Institute of Functional Genomics, University of Regensburg, Regensburg, Germany.
3
Institute of Biophysics and Physical Biochemistry, University of Regensburg, Regensburg, Germany.
4
Institute of Biochemistry, Genetics and Microbiology, University of Regensburg, Regensburg, Germany Markus.Kretz@ur.de.

Abstract

Several long non-coding RNAs (lncRNAs) act as regulators of cellular homeostasis; however, few of these molecules were functionally characterized in a mature human tissue environment. Here, we report that the lncRNA LINC00941 is a crucial regulator of human epidermal homeostasis. LINC00941 is enriched in progenitor keratinocytes and acts as a repressor of keratinocyte differentiation. Furthermore, LINC00941 represses SPRR5, a previously uncharacterized molecule, which functions as an essential positive regulator of keratinocyte differentiation. Interestingly, 54.8% of genes repressed in SPRR5-deficient epidermal tissue are induced in LINC00941-depleted organotypic epidermis, suggesting a common mode of action for both molecules.

KEYWORDS:

LINC00941; SPRR5; differentiation; epidermis; long non‐coding RNA

PMID:
30622217
DOI:
10.15252/embr.201846612

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