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Dev Cell. 2019 Jan 7;48(1):1-2. doi: 10.1016/j.devcel.2018.12.014.

An Electric Take on Neural Fate and Cortical Development.

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MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Francis Crick Avenue, Cambridge, UK. Electronic address:


Membrane potential is well-studied in neuronal physiology, but its role in brain development and cell fate determination is less well understood. In two recent studies, bioelectric properties of progenitors and migrating neurons are shown to be tightly regulated, and their disruption leads to abnormalities in fate determination and neuronal positioning.

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