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J Antimicrob Chemother. 1988 Jul;22 Suppl A:17-22.

Bacterial resistance to antibiotics as a function of outer membrane permeability.

Author information

1
Department of Microbiology and Immunology, University of California, Berkeley 94720.

Abstract

The outer membrane of Gram-negative bacteria serves as barrier to permeation. Transport across this barrier often occurs through channels created by porins. Changes in these porins can account for antibiotic resistance. The combination of a permeability barrier and beta-lactamases in the periplasmic space leads to a situation in which concentrations, at the target, of even third-generation cephalosporins, can be significantly decreased.

PMID:
3062001
DOI:
10.1093/jac/22.supplement_a.17
[Indexed for MEDLINE]

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