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Front Pediatr. 2018 Dec 12;6:394. doi: 10.3389/fped.2018.00394. eCollection 2018.

Modeling Inflammation in Autism Spectrum Disorders Using Stem Cells.

Author information

1
Laboratory of Disease Modeling, Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
2
Laboratory of Genetics, The Salk Institute, La Jolla, CA, United States.
3
School of Arts, Sciences and Humanities, University of São Paulo, São Paulo, Brazil.

Abstract

Recent reports show an increase in the incidence of Autism Spectrum Disorders (ASD) to 1 in every 59 children up to 8 years old in 11 states in North America. Induced pluripotent stem cell (iPSC) technology offers a groundbreaking platform for the study of polygenic neurodevelopmental disorders in live cells. Robust inflammation states and immune system dysfunctions are associated with ASD and several cell types participate on triggering and sustaining these processes. In this review, we will examine the contribution of neuroinflammation to the development of autistic features and discuss potential therapeutic approaches. We will review the available tools, emphasizing stem cell modeling as a technology to investigate the various molecular pathways and different cell types involved in the process of neuroinflammation in ASD.

KEYWORDS:

autism spectrum disorder (ASD); disease modeling; induced pluripotent stem (iPS) cells; neurodevelopmental disorders; neuroinflammation

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