Format

Send to

Choose Destination
Int J Addict. 1988 May;23(5):449-67.

Comparative study of the abuse liability of alprazolam, lorazepam, diazepam, methaqualone, and placebo.

Author information

1
McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02178.

Abstract

Subjective effects of two benzodiazepines--alprazolam and lorazepam--were compared with two drugs of known abuse potential--diazepam and methaqualone--and placebo. This double-blind, crossover trial tested 30 casual recreational sedative users in a seminaturalistic setting. Methaqualone was more euphoriant and less sedative than the benzodiazepines. Diazepam and lorazepam were more euphoriant than placebo; alprazolam's euphoriant effect did not differ from these treatments. On other measures of abuse liability the benzodiazepines rated similarly, diazepam rating highest.

PMID:
3061941
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center