Format

Send to

Choose Destination
Front Immunol. 2018 Dec 14;9:2893. doi: 10.3389/fimmu.2018.02893. eCollection 2018.

Human Hookworm Infection Enhances Mycobacterial Growth Inhibition and Associates With Reduced Risk of Tuberculosis Infection.

Author information

1
Nuffield Department of Medicine, The Jenner Institute, University of Oxford, Oxford, United Kingdom.
2
Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom.
3
Royal Centre for Defence Medicine, Joint Medical Command, Birmingham, United Kingdom.
4
Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
5
Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, United Kingdom.
6
Department of Infectious Diseases, Northwick Park Hospital, London, United Kingdom.
7
Institute of Infectious Disease and Molecular Medicine and Division of Immunology, University of Cape Town, Cape Town, South Africa.
8
Department of Infectious Diseases, The Friarage Hospital, Northallerton, United Kingdom.
9
Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom.

Abstract

Soil-transmitted helminths and Mycobacterium tuberculosis frequently coincide geographically and it is hypothesized that gastrointestinal helminth infection may exacerbate tuberculosis (TB) disease by suppression of Th1 and Th17 responses. However, few studies have focused on latent TB infection (LTBI), which predominates globally. We performed a large observational study of healthy adults migrating from Nepal to the UK (n = 645). Individuals were screened for LTBI and gastrointestinal parasite infections. A significant negative association between hookworm and LTBI-positivity was seen (OR = 0.221; p = 0.039). Hookworm infection treatment did not affect LTBI conversions. Blood from individuals with hookworm had a significantly greater ability to control virulent mycobacterial growth in vitro than from those without, which was lost following hookworm treatment. There was a significant negative relationship between mycobacterial growth and eosinophil counts. Eosinophil-associated differential gene expression characterized the whole blood transcriptome of hookworm infection and correlated with improved mycobacterial control. These data provide a potential alternative explanation for the reduced prevalence of LTBI among individuals with hookworm infection, and possibly an anti-mycobacterial role for helminth-induced eosinophils.

KEYWORDS:

LTBI; eosinophil; growth inhibition; hookworm; latent tuberculosis; tuberculosis

PMID:
30619265
PMCID:
PMC6302045
DOI:
10.3389/fimmu.2018.02893
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Frontiers Media SA Icon for PubMed Central
Loading ...
Support Center