Format

Send to

Choose Destination
Front Psychiatry. 2018 Dec 18;9:697. doi: 10.3389/fpsyt.2018.00697. eCollection 2018.

Abnormal Default Mode Network Homogeneity in Treatment-Naive Patients With First-Episode Depression.

Author information

1
Department of Neurology, The First Affiliated Hospital, Guangxi Medical University, Nanning, China.
2
Department of Otorhinolaryngology and Head and Neck Surgery, The First Affiliated Hospital, Guangxi Medical University, Nanning, China.
3
Department of Radiology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China.
4
The First Affiliated Hospital, Guangxi Medical University, Nanning, China.

Abstract

Background and Objective: The default mode network (DMN) may be an important component involved in the broad-scale cognitive problems seen in patients with first-episode treatment-naive depression. Nevertheless, information is scarce regarding the changes in network homogeneity (NH) found in the DMN of these patients. Therefore, in this study, we explored the NH of the DMN in patients with first-episode treatment-naive depression. Methods: The study included 66 patients and 74 control participants matched by age, gender, educational level and health status who underwent resting-state functional magnetic resonance imaging (rs-fMRI) and the attentional network test (ANT). To assess data, the study utilizes NH and independent component analysis (ICA). Additionally, Spearman's rank correlation analysis is performed among significantly abnormal NH in depression patients and clinical measurements and executive control reaction time (ECRT). Results: In comparison with the control group, patients with first-episode treatment-naive depression showed lower NH in the bilateral angular gyrus (AG), as well as increased NH in the bilateral precuneus (PCu) and posterior cingulate cortex (PCC). Likewise, patients with first-episode treatment-naive depression had longer ECRT. No significant relation was found between abnormal NH values and the measured clinical variables. Conclusions: Our results suggest patients with first-episode treatment-naive depression have abnormal NH values in the DMN. This highlights the significance of DMN in the pathophysiology of cognitive problems in depression. Our study also found alterations in executive functions in patients with first-episode treatment-naive depression.

KEYWORDS:

attentional network test; default mode network; depression; network homogeneity; rest-fMRI

Supplemental Content

Full text links

Icon for Frontiers Media SA Icon for PubMed Central
Loading ...
Support Center