Send to

Choose Destination
Front Aging Neurosci. 2018 Dec 18;10:415. doi: 10.3389/fnagi.2018.00415. eCollection 2018.

Tooth Loss Is Associated With Increased Risk of Dementia and With a Dose-Response Relationship.

Author information

Department of Neurology, Taihe Hospital, Hubei University of Medicine, Shiyan, China.
Department of Evidence-Based Medicine and Clinical Epidemiology, Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Second Clinical College of Wuhan University, Wuhan, China.
Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan, China.
Department of Stomatology, Guangzhou Hospital of Integrated Traditional and West Medicine, Guangzhou, China.


Objective: Both tooth loss and dementia are age-related and frequently-occurring diseases. Increasing attention has been given to explore the pathogenesis related to oral-brain function disorders. The present study was performed to evaluate the association between tooth loss and dementia through a dose-response meta-analysis. Methods: Relevant cohort studies were searched from online databases up until June 20, 2018, which examined the association between tooth loss and the risk of dementia. Literature selection according to inclusion and exclusion criteria, as well as data extraction from included studies were completed independently by two reviewers. Data syntheses in this meta-analysis were performed using Stata 12.0 software. Results: A total of 8 cohort studies were included, containing a total of 14,362 samples and 2,072 dementia patients. The result of the meta-analysis indicated that patients with tooth loss faced a 1.34 times greater risk of developing dementia (RR = 1.34,95% CI = 1.19-1.51). The result from this dose-response meta-analysis in a linear model, suggested that every missed tooth might increase the risk of dementia by 1.01 times (RR = 1.01, 95%CI = 1.00-1.02). Further subgroup analyses pointed out that tooth loss patients without dentures may have a higher risk of dementia than those with dentures (with denture: RR = 0.98, 95% CI = 0.87-1.10; without denture: RR = 1.53, 95% CI = 1.19-1.97); at the same time, the study design, study area and education level of the study participants, might also have some effect on the results. Conclusions: Tooth loss may be a risk factor for the development of dementia. In addition, there is a dose-response relationship with the increase of missing teeth.


dementia; dose-response analysis; meta-analysis; periodontal disease; risk factor; tooth loss

Supplemental Content

Full text links

Icon for Frontiers Media SA Icon for PubMed Central
Loading ...
Support Center