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Nat Rev Microbiol. 2019 Jan 7. doi: 10.1038/s41579-018-0134-9. [Epub ahead of print]

The evolution of Zika virus from Asia to the Americas.

Liu ZY1,2,3, Shi WF4, Qin CF5,6.

Author information

1
Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing, China.
2
The No. 8 People's Hospital, Guangzhou Medical University, Guangzhou, China.
3
School of Medicine (Shenzhen), Sun Yat-sen University, Guangzhou, China.
4
Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong, Taishan Medical College, Taian, China. shiwf@ioz.ac.cn.
5
Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing, China. qincf@bmi.ac.cn.
6
The No. 8 People's Hospital, Guangzhou Medical University, Guangzhou, China. qincf@bmi.ac.cn.

Abstract

Zika virus (ZIKV) was once considered an obscure member of the large and diverse family of mosquito-borne flaviviruses, and human infections with ZIKV were thought to be sporadic, with mild and self-limiting symptoms. The large-scale ZIKV epidemics in the Americas and the unexpected uncovering of a link to congenital birth defects escalated ZIKV infections to the status of a global public health emergency. Recent studies that combined reverse genetics with modelling in multiple systems have provided evidence that ZIKV has acquired additional amino acid substitutions at the same time as congenital Zika syndrome and other birth defects were detected. In this Progress article, we summarize the evolution of ZIKV during its spread from Asia to the Americas and discuss potential links to pathogenesis.

PMID:
30617340
DOI:
10.1038/s41579-018-0134-9

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