Format

Send to

Choose Destination
J Immunol. 2019 Jan 15;202(2):351-359. doi: 10.4049/jimmunol.1801208.

The Multifaceted B Cell Response to Influenza Virus.

Author information

1
Center for Comparative Medicine, University of California, Davis, Davis, CA 95616.
2
Graduate Group in Immunology, University of California, Davis, Davis, CA 95616; and.
3
Center for Comparative Medicine, University of California, Davis, Davis, CA 95616; nbaumgarth@ucdavis.edu.
4
Department of Pathology, Microbiology and Immunology, University of California, Davis, Davis, CA 95616.

Abstract

Protection from yearly recurring, highly acute infections with a pathogen that rapidly and continuously evades previously induced protective neutralizing Abs, as seen during seasonal influenza virus infections, can be expected to require a B cell response that is too highly variable, able to adapt rapidly, and able to reduce morbidity and death when sterile immunity cannot be garnered quickly enough. As we outline in this Brief Review, the influenza-specific B cell response is exactly that: it is multifaceted, involves both innate-like and conventional B cells, provides early and later immune protection, employs B cells with distinct BCR repertoires and distinct modes of activation, and continuously adapts to the ever-changing virus while enhancing overall protection. A formidable response to a formidable pathogen.

PMID:
30617116
PMCID:
PMC6327962
[Available on 2020-01-15]
DOI:
10.4049/jimmunol.1801208

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center