Format

Send to

Choose Destination
Stem Cell Res. 2019 Jan;34:101366. doi: 10.1016/j.scr.2018.101366. Epub 2018 Dec 27.

Generation of induced pluripotent stem cell line (ZZUi0013-A) from a 65-year-old patient with a novel MEOX2 gene mutation in Alzheimer's disease.

Author information

1
Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
2
Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. Electronic address: xuyuming@zzu.edu.cn.
3
Center for Stem Cell and Regenerative Medicine, Department of Basic Medical Sciences, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China; Institute of Hematology, Zhejiang University, Hangzhou, Zhejiang 310058, China. Electronic address: zhgene@gmail.com.

Abstract

MEOX2 mutation has been reported as a potential cause of familial Alzheimer's disease. Recently, a novel MEOX2 mutation was identified in a family with Alzheimer's disease. The dermal fibroblasts of the patient were obtained and successfully transformed into induced pluripotent stem cells (iPSCs), employing episomal plasmids expressing OCT3/4, SOX2, KLF4, LIN28, and L-MYC. Our model may offer a good platform for further research on the pathomechanism, drug testing, and gene therapy of this disease.

PMID:
30616143
DOI:
10.1016/j.scr.2018.101366
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center