Format

Send to

Choose Destination
Ageing Res Rev. 2019 Mar;50:9-18. doi: 10.1016/j.arr.2019.01.003. Epub 2019 Jan 4.

Exploring the relationship between physical activity, beta-amyloid and tau: A narrative review.

Author information

1
School of Psychology and Exercise Science, Murdoch University, Murdoch, Western Australia, Australia; Australian Alzheimer's Research Foundation, Sarich Neuroscience Research Institute, Nedlands, Western Australia, Australia; Ageing, Cognition and Exercise Research Group, School of Psychology and Exercise Science, Murdoch University, Murdoch, Western Australia, Australia. Electronic address: b.brown@murdoch.edu.au.
2
School of Psychology and Exercise Science, Murdoch University, Murdoch, Western Australia, Australia; Ageing, Cognition and Exercise Research Group, School of Psychology and Exercise Science, Murdoch University, Murdoch, Western Australia, Australia.
3
Australian Alzheimer's Research Foundation, Sarich Neuroscience Research Institute, Nedlands, Western Australia, Australia; Ageing, Cognition and Exercise Research Group, School of Psychology and Exercise Science, Murdoch University, Murdoch, Western Australia, Australia; School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.

Abstract

Several prospective cohort studies have reported an association between higher levels of physical activity and decreased risk of cognitive decline and dementia, years later. To support physical activity as a preventative measure against dementia, including Alzheimer's disease (AD; the most common form of dementia), evidence regarding the underlying mechanisms is vital. Here, we review previous work examining the role of physical activity in modulating levels of AD pathological hallmarks, beta-amyloid (Aβ) and tau (in the brain, cerebrospinal fluid and blood). Robust evidence from transgenic animal studies suggests that physical activity (voluntary wheel running) and exercise (forced wheel running) are implicated in lowering levels of brain Aβ and tau. Nevertheless, evidence from human studies, utilising measurements from positron emission tomography and cerebrospinal fluid biomarkers, is less consistent. Rigorous randomised controlled trials utilising long exercise interventions are vital to further understand the relationship between physical activity and Alzheimer's disease.

KEYWORDS:

Alzheimer’s disease; Beta-amyloid; Dementia; Exercise; Physical activity; Tau

PMID:
30615936
DOI:
10.1016/j.arr.2019.01.003
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center