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Tissue Eng Part A. 2019 Feb 27. doi: 10.1089/ten.TEA.2018.0215. [Epub ahead of print]

Local Delivery of Brain-Derived Neurotrophic Factor Enables Behavioral Recovery and Tissue Repair in Stroke-Injured Rats.

Obermeyer JM1,2,3, Tuladhar A2,3, Payne SL1,2,3, Ho E1,2,3, Morshead CM2,3,4, Shoichet MS1,2,3,5.

Author information

1
1 Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Canada.
2
2 Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Canada.
3
3 Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Canada.
4
4 Department of Surgery, University of Toronto, Toronto, Canada.
5
5 Department of Chemistry, University of Toronto, Toronto, Canada.

Abstract

We developed a biocomposite that can be mixed with brain-derived neurotrophic factor (BDNF) and dispensed onto the surface of the brain to provide sustained, local release of the protein using a procedure that avoids additional damage to neural tissue. The composite is simple to fabricate, and provides sustained release without nanoparticle encapsulation of BDNF, preserving material and protein bioactivity. We demonstrate that when delivered epicortically to a rat model of stroke, this composite allows BDNF to diffuse into the brain, resulting in enhanced behavioral recovery and synaptic plasticity in the contralesional hemisphere.

KEYWORDS:

BDNF; behavior; hydrogel; nanoparticle; plasticity; stroke

PMID:
30612516
DOI:
10.1089/ten.TEA.2018.0215

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