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Fertil Steril. 2019 Feb;111(2):219-226. doi: 10.1016/j.fertnstert.2018.10.036. Epub 2019 Jan 2.

Mitochondria as a tool for oocyte rejuvenation.

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IVI-RMA Valencia, Valencia, Spain; IVI Foundation, Valencia, Spain. Electronic address:
IVI-RMA Valencia, Valencia, Spain; IVI Foundation, Valencia, Spain.
IVI-RMA Valencia, Valencia, Spain.


Ovarian aging leads to a decrease in the quantity and quality of oocytes. Aged oocytes have significantly reduced amounts of mitochondria, the energy factories of cells, leading to lower fertilization rates and poor embryonic development. Various techniques have tried to use heterologous or autologous sources of mitochondria to reestablish oocyte health by providing more energy. However, heterologous sources are no longer used owing to the known risk of heteroplasmy. Although autologous methods have recently been tested in humans, they have not shown a clear improvement in embryo quality. In this review, we describe the techniques that have been tested in recent years to provide a state of the art on oocyte rejuvenation through extra injection of mitochondria.


Mitochondrial supplementation; egg precursor cells; heterologous and autologous mitochondria; oocyte competence

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