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Respir Res. 2019 Jan 5;20(1):3. doi: 10.1186/s12931-018-0962-1.

Circular RNAs: a rising star in respiratory diseases.

Author information

1
Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.
2
Department of Infectious Diseases, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.
3
Department of Geriatrics, Shanghai Institute of Geriatrics, Huadong Hospital, Fudan University, 221 West Yan An Road, Shanghai, 200040, China. xiashijinhd@163.com.
4
Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China. ylsong70@163.com.

Abstract

Circular RNAs (CircRNAs), as a new class of non-coding RNA molecules that, unlike linear RNAs, have covalently closed loop structures from the ligation of exons, introns, or both. CircRNAs are widely expressed in various organisms in a specie-, tissue-, disease- and developmental stage-specific manner, and have been demonstrated to play a vital role in the pathogenesis and progression of human diseases. An increasing number of recent studies has revealed that circRNAs are intensively associated with different respiratory diseases, including lung cancer, acute respiratory distress syndrome, pulmonary hypertension, pulmonary tuberculosis, and silicosis. However, to the best of our knowledge, there has been no systematic review of studies on the role of circRNAs in respiratory diseases. In this review, we elaborate on the biogenesis, functions, and identification of circRNAs and focus particularly on the potential implications of circRNAs in respiratory diseases.

KEYWORDS:

Alternative splicing; Circular RNAs; Non-coding RNA; Respiratory diseases; miRNA sponge

PMID:
30611252
PMCID:
PMC6321672
DOI:
10.1186/s12931-018-0962-1
[Indexed for MEDLINE]
Free PMC Article

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