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Stem Cell Res. 2018 Dec 5;34:101351. doi: 10.1016/j.scr.2018.11.012. [Epub ahead of print]

Generation of an induced pluripotent stem cell cohort suitable to investigate sporadic Alzheimer's Disease.

Author information

1
BioMedX Innovation Center, Heidelberg, Germany.
2
Institut für Humangenetik, Medizinische Hochschule Hannover, Germany.
3
BioMedX Innovation Center, Heidelberg, Germany. Electronic address: ehrnhoefer@bio.mx.

Abstract

Alzheimer's Disease (AD) is the major cause of dementia in the elderly, and cortical neurons differentiated from patient-derived induced pluripotent stem cells (iPSCs) can recapitulate disease phenotypes such as tau phosphorylation or amyloid beta (Aß) deposition. Here we describe the generation of an iPSC cohort consisting of 2 sporadic AD cases and 3 controls, derived from dermal fibroblasts. All lines were karyotypically normal, showed expression of stem cell markers and efficiently differentiated into cells of all three germ layers.

PMID:
30611016
DOI:
10.1016/j.scr.2018.11.012
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