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ACS Appl Mater Interfaces. 2019 Jan 30;11(4):4447-4469. doi: 10.1021/acsami.8b20429. Epub 2019 Jan 17.

Triple-Bioinspired Burying/Crosslinking Interfacial Coassembly Strategy for Layer-by-Layer Construction of Robust Functional Bioceramic Self-Coatings for Osteointegration Applications.

Author information

1
Department of Materials Science and Engineering, College of Engineering , Peking University , Beijing 100871 , China.
2
Center for Biomedical Materials and Tissue Engineering, Academy for Advanced Interdisciplinary Studies , Peking University , Beijing 100871 , China.
3
Department of Orthopaedics and Traumatology , The University of Hong Kong , 21 Sassoon Road , Pokfulam 999077 , Hong Kong China.
4
Department of Orthopedic Surgery, West China Hospital , Sichuan University , 37 Guoxue Road , Chengdu 610041 , China.
5
Biomaterials and Tissue Engineering Research Unit, School of AMME , The University of Sydney , Sydney 2006 , Australia.

Abstract

Coating bioceramics of inherent bioactivity onto biometallic implants is a straightforward yet promising solution to address poor osteointegration of the latter. One step further, it would be a nontrivial accomplishment to develop a mild, cheap, and universal route to firmly stabilizing, in principle, any ceramics onto any implant substrate, while imparting expectedly versatile biofunctional performances. Herein, we describe a triple-bioinspired burying/cross-linking interfacial coassembly strategy for enabling such ceramic coatings, which ingeniously fuses bioinspiration from sea rocks (burying assisted particle immobilization), marine mussels (universal adhesion and versatile chemical reactivity), and reef-building oysters (cross-linking rendered cohesion). Specifically, surface functionalized, aqueous dispersed ceramic particles were buried within an substrate-anchored organic matrix of polyelectrolyte multilayers (i.e., (poly(ether imide) (PEI)/poly(sodium-p-styrenesulfonate) (PSS)) n), through a new inorganic-organic hybrid layer-by-layer (LBL) coassembly scheme wherein mussel (oyster) inspired adhesive (cohesive) chemistries were exquisitely orchestrated. As a conceptual demonstration, bioactive baghdadite (Ca3ZrSi2O9) was synthesized as model ceramics, with which we constructed on medical titanium robust, biomimetic, and cross-linkable LBL self-assemblies harnessing the said strategy. Intimate substrate contacts and well-defined buried inorganic-organic interfaces were evidently seen, together with good structural and chemical stabilities, especially after cross-linking. Sustained bioactive ion releasing and appreciable biomineralization activity were confirmed in vitro. Subsequently, biological performances of the assemblies were systematically investigated with respect to surface hydrophilicity, protein adsorption, and osteoblast functions. Additionally, nanosilver deposition, which imparted the surfaces with added antibacterial potencies, was used to exemplify the strategy's versatility in allowing multifunctionality. What's more, the flexibility of our approach was testified through modifying clinically relevant complicated 3D porous scaffolds. Overall, our strategy basically met the design expectations, boding well for future medical adoption. This study offers the promise of an alternative broadly useful avenue to bioactive and functional surface design of bone implants. It may also provide insights into other multiple-bioinspired materials/interfaces for biological and other applications.

KEYWORDS:

antibacterial functionality; bioinspired layer-by-layer assembly; calcium silicate ceramics; implant coatings; osteogenic activity; polydopamine

PMID:
30609379
DOI:
10.1021/acsami.8b20429
[Indexed for MEDLINE]

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