Format

Send to

Choose Destination
Medicine (Baltimore). 2019 Jan;98(1):e13937. doi: 10.1097/MD.0000000000013937.

Nutrient pattern analysis in critically ill patients using Omics technology (NAChO) - Study protocol for a prospective observational study.

Author information

1
Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland.
2
Metabolic Research Unit, Department Cardiology and Pneumology, University of Göttingen, Göttingen, Germany.
3
Neuro Research Center, Charite University Medicine Berlin, Berlin, Germany.
4
Musculoskeletal Science and Sports Medicine Research Centre, Manchester Metropolitan University, Manchester, United Kingdom.
5
Clinical Cytomics Facility, University Institute of Clinical Chemistry and Centre of Laboratory Medicine.
6
Department of Neurology.
7
Department of Plastic Surgery.
8
Depts. of Neurosurgery and Neurology, Inselspital, Bern University Hospital, University of Bern.
9
Nestlé Research, vers-chez-les-Blanc, Lausanne.
10
Swiss Vitamin Institute, Epalinges, Switzerland.
11
Nestlé Health Science.

Abstract

INTRODUCTION:

Intensive care unit-acquired weakness (ICU-AW) is often observed in critically ill patients with prolonged intensive care unit (ICU) stay. We hypothesized that evolving metabolic abnormalities during prolonged ICU stay are reflected by changing nutrient patterns in blood, urine and skeletal muscle, and that these patterns differ in patients with/without ICU-AW and between patients with/without sepsis.

METHODS:

In a prospective single-center observational trial, we aim to recruit 100 critically ill patients (ICU length of stay ≥ 5 days) with severe sepsis/septic shock ("sepsis group", n = 50) or severe head trauma/intracerebral hemorrhage ("CNS group", n = 50). Patients will be sub-grouped for presence or absence of ICU-AW as determined by the Medical Research Council sum score. Blood and urine samples will be collected and subjected to comprehensive nutrient analysis at different time points by targeted quantitative mass spectrometric methods. In addition, changes in muscular tissue (biopsy, when available), muscular architecture (ultrasound), electrophysiology, body composition analyses (bioimpedance, cerebral magnetic resonance imaging), along with clinical status will be assessed. Patients will be followed-up for 180 and 360 days including assessment of quality of life.

DISCUSSION:

Key objective of this trial is to assess changes in nutrient pattern in blood and urine over time in critically ill patients with/without ICU-AW by using quantitative nutrient analysis techniques. Peer-reviewed published NAChO data will allow for a better understanding of metabolic changes in critically ill patients on standard liquid enteral nutrition and will likely open up new avenues for future therapeutic and nutritional interventions.

PMID:
30608424
DOI:
10.1097/MD.0000000000013937
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wolters Kluwer
Loading ...
Support Center