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J Mol Neurosci. 2019 Mar;67(3):373-387. doi: 10.1007/s12031-018-1237-5. Epub 2019 Jan 3.

The Role of Vitamins in Autism Spectrum Disorder: What Do We Know?

Author information

1
Council for Nutritional and Environmental Medicine (CONEM), Toften 24, 8610, Mo i Rana, Norway. bjorklund@conem.org.
2
Department of Food Science and Nutrition, College of Agricultural and Marine Sciences, Sultan Qaboos University, Muscat, Oman.
3
Department of Family Medicine and Public Health, College of Medicine and Health Science, Sultan Qaboos University, Muscat, Oman.
4
Department of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt.
5
CONEM Upper Egypt Pediatric Research Group, Assiut University, Assiut, Egypt.
6
Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran.
7
Department of Environmental Sciences, Jahangirnagar University, Dhaka, Bangladesh.
8
Graduate School of Environmental Science, Hokkaido University, Sapporo, Japan.
9
Department of Community Health Nursing, Faculty of Nursing, Assiut University, Assiut, Egypt.
10
Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
11
CONEM Scientific Secretary, Verona, Italy.
12
Institute of General and Ecological Chemistry, Department of Chemistry, Technical University of Lodz, Lodz, Poland.
13
CONEM Poland Chemistry and Nutrition Research Group, Lodz University of Technology, Lodz, Poland.

Abstract

Vitamin or mineral supplementation is considered to be the most commonly used medical treatment for autism spectrum disorder (ASD), in addition to other interventions such as neurological and psychological interventions. There is not much evidence of therapeutic efficacy between vitamin and mineral supplementation and improvements in ASD. However, several researchers have noted that patients with ASD have various metabolic and nutritional abnormalities including issues with sulfation, methylation, glutathione redox imbalances, oxidative stress, and mitochondrial dysfunction. There is some evidence that vitamin and mineral supplementation may support these basic physiologic processes. Recently, the nutritional status of ASD patients has been gaining focus in this particular area. Pointing out the nutritional status as a potential etiological factor for attention/communication disorders, more importance has been given to this particular point. Moreover, autistic specific considerations like the feature and behavior of ASD might be increased or at least fall in the higher risk due to the sub-optimal nutritional status.

KEYWORDS:

Autism; Nutrition; Vitamin supplementation; Vitamins

PMID:
30607900
DOI:
10.1007/s12031-018-1237-5

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