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Cerebellum. 2019 Jan 3. doi: 10.1007/s12311-018-0999-1. [Epub ahead of print]

Task Force Paper On Cerebellar Transplantation: Are We Ready to Treat Cerebellar Disorders with Cell Therapy?

Author information

1
Department of Pathophysiology, Faculty of Medicine in Pilsen, Charles University, alej Svobody 1655/76, 323 00, Plzen, Czech Republic.
2
Laboratory of Neurodegenerative Disorders, Biomedical Center, Faculty of Medicine in Pilsen, Charles University, alej Svobody 1655/76, 323 00, Plzen, Czech Republic.
3
Department of Neuroscience Rita Levi-Montalcini, University of Turin, 10126, Turin, Italy.
4
Neuroscience Institute Cavalieri Ottolenghi, Orbassano, 10043, Turin, Italy.
5
Department of Neurophysiology and Neural Repair, Gunma University Graduate School of Medicine, 3-39-22, Maebashi, Gunma, 371-8511, Japan.
6
Neurosurgery, Dipartimento di Scienze Clinico-Chirurgiche Diagnostiche e Pediatriche, Fondazione IRCCS Policlinico S. Matteo, Università degli Studi di Pavia, 27100, Pavia, Italy.
7
Istituto di Genetica Molecolare - CNR, 27100, Pavia, Italy.
8
Medical Education Promotion Center, Tokyo Medical University, Tokyo, Japan.
9
IBPS, UMR8256 Biological Adaptation and Ageing, Sorbonne Université and CNRS, Paris, France.
10
Department of Neurology, CHU-Charleroi, 6000, Charleroi, Belgium. mmanto@ulb.ac.be.
11
Service des Neurosciences, Université de Mons, 7000, Mons, Belgium. mmanto@ulb.ac.be.

Abstract

Restoration of damaged central nervous system structures, functional recovery, and prevention of neuronal loss during neurodegenerative diseases are major objectives in cerebellar research. The highly organized anatomical structure of the cerebellum with numerous inputs/outputs, the complexity of cerebellar functions, and the large spectrum of cerebellar ataxias render therapies of cerebellar disorders highly challenging. There are currently several therapeutic approaches including motor rehabilitation, neuroprotective drugs, non-invasive cerebellar stimulation, molecularly based therapy targeting pathogenesis of the disease, and neurotransplantation. We discuss the goals and possible beneficial mechanisms of transplantation therapy for cerebellar damage and its limitations and factors determining outcome.

KEYWORDS:

Ataxias; Cerebellar reserve; Cerebellum; Neurotransplantation; Stem cells

PMID:
30607797
DOI:
10.1007/s12311-018-0999-1

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