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J Autism Dev Disord. 2019 Jan 3. doi: 10.1007/s10803-018-3860-y. [Epub ahead of print]

A Randomised-Controlled Trial of Vitamin D and Omega-3 Long Chain Polyunsaturated Fatty Acids in the Treatment of Core Symptoms of Autism Spectrum Disorder in Children.

Author information

1
College of Health, Massey University, Auckland, 0745, New Zealand.
2
Commonwealth Scientific Industrial Research Organisation, Food and Nutrition Flagship, Adeliade, Australia.
3
Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
4
School of Medicine, Lipid Research Centre, Illawarra Health & Medical Research Institute, University of Wollongong, Wollongong, Australia.
5
University of Auckland, Auckland, New Zealand.
6
College of Health, Massey University, Auckland, 0745, New Zealand. p.r.vonhurst@massey.ac.nz.

Abstract

We evaluated the efficacy of vitamin D (VID), omega-3 long chain polyunsaturated fatty acids (omega-3 LCPUFA, OM), or both (VIDOM) on core symptoms of ASD. New Zealand children with ASD (n = 73; aged 2.5-8.0 years) received daily 2000 IU vitamin D3, 722 mg docosahexaenoic acid, both, or placebo. Outcome measures were Social Responsiveness Scale (SRS) and Sensory Processing Measure (SPM). Of 42 outcome measures comparisons (interventions vs. placebo), two showed greater improvements (P = 0.03, OM and VIDOM for SRS-social awareness) and four showed trends for greater improvements (P < 0.1, VIDOM for SRS-social communicative functioning, OM for SRS-total, VIDOM for SPM-taste/smell and OM for SPM-balance/motion). Omega-3 LCPUFA with and without vitamin D may improve some core symptoms of ASD but no definitive conclusions can be made.

KEYWORDS:

Autism; Children; Core symptoms; Intervention; Omega-3; Supplement; Vitamin D

PMID:
30607782
DOI:
10.1007/s10803-018-3860-y

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