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Ann Biomed Eng. 2019 Jan 3. doi: 10.1007/s10439-018-02191-z. [Epub ahead of print]

Data-Augmented Modeling of Intracranial Pressure.

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Mechanical Engineering, University of California, Berkeley, CA, USA.
Aerospace and Mechanical Engineering, Center of Informatics and Computational Science, University of Notre Dame, Notre Dame, IN, USA.
Department of Physiological Nursing, Department of Neurological surgery, Institute of Computational Health Sciences, UCSF Joint Bio-Engineering Graduate Program, University of California, San Francisco, CA, USA.
Mechanical Engineering, University of California, Berkeley, CA, USA.


Precise management of patients with cerebral diseases often requires intracranial pressure (ICP) monitoring, which is highly invasive and requires a specialized ICU setting. The ability to noninvasively estimate ICP is highly compelling as an alternative to, or screening for, invasive ICP measurement. Most existing approaches for noninvasive ICP estimation aim to build a regression function that maps noninvasive measurements to an ICP estimate using statistical learning techniques. These data-based approaches have met limited success, likely because the amount of training data needed is onerous for this complex applications. In this work, we discuss an alternative strategy that aims to better utilize noninvasive measurement data by leveraging mechanistic understanding of physiology. Specifically, we developed a Bayesian framework that combines a multiscale model of intracranial physiology with noninvasive measurements of cerebral blood flow using transcranial Doppler. Virtual experiments with synthetic data are conducted to verify and analyze the proposed framework. A preliminary clinical application study on two patients is also performed in which we demonstrate the ability of this method to improve ICP prediction.


Cerebrovascular dynamics; Data assimilation; Patient-specific modeling; Transcranial Doppler


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