Format

Send to

Choose Destination
Oncologist. 2019 Jan 3. pii: theoncologist.2018-0422. doi: 10.1634/theoncologist.2018-0422. [Epub ahead of print]

T-Cell Lymphopenia in Patients with Advanced Thyroid Carcinoma Is Associated with Poor Prognosis.

Author information

1
Radiotherapy & OncoImmunology Laboratory, Department of Radiation Oncology, Radboud University Medical Center, Nijmegen, The Netherlands.
2
Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
3
Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands.
4
Department for Genomics & Immunoregulation, Life and Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany.
5
Division of Endocrinology, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
6
Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands romana.netea-maier@radboudumc.nl.

Abstract

BACKGROUND:

Aggressive forms of thyroid carcinoma (TC) show an abundant infiltration of immune cells, and this correlates with prognosis. However, little is known about circulating immune cell levels in advanced TC.

OBJECTIVE:

Investigate T-cell and myeloid-derived suppressor cell (MDSC) levels in peripheral blood of patients with advanced TC and correlate them with survival.

METHODS:

T cells and MDSCs were quantified by flow cytometry in peripheral blood from nine patients with advanced TC and nine healthy volunteers.

RESULTS:

No significant differences in MDSC or regulatory T-cell levels were detected between patients with TC and healthy controls. CD3, CD4, and CD8 T-cell levels were significantly lower in patients with TC. CD3 and CD4 T-cell levels further decreased in patients with survival of less than 1 month.

CONCLUSION:

These data suggest that T-cell lymphopenia in patients with TC indicates an aggressive tumor behavior and might influence therapeutic choices in the future. Restoring T-cell levels may become a potential therapeutic option within the multitarget approaches.

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center