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Semin Nephrol. 2019 Jan;39(1):107-116. doi: 10.1016/j.semnephrol.2018.10.009.

Gut Microbiota-Kidney Cross-Talk in Acute Kidney Injury.

Author information

1
Department of Medicine, Johns Hopkins University, Baltimore, Maryland; Department of Pediatric Nephrology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China.
2
Department of Medicine, Johns Hopkins University, Baltimore, Maryland.
3
Department of Physiology, Johns Hopkins University, Baltimore, Maryland.
4
Department of Pathology, Johns Hopkins University, Baltimore, Maryland.
5
Department of Medicine, Johns Hopkins University, Baltimore, Maryland. Electronic address: hrabb1@jhmi.edu.

Abstract

The recent surge in research on the intestinal microbiota has greatly changed our understanding of human biology. Significant technical advances in DNA sequencing analysis and its application to metagenomics and metatranscriptomics has profoundly enhanced our ability to quantify and track complex microbial communities and to begin understanding their impact on human health and disease. This has led to a better understanding of the relationships between the intestinal microbiome and renal physiology/pathophysiology. In this review, we discuss the interactions between intestinal microbiota and kidney. We focus on select aspects including the intestinal barrier, immunologic and soluble mediators of microbiome effects, and effects of dysbiosis on acute kidney injury. Relevant studies on microbiome changes in other renal diseases are highlighted. We also introduce potential mechanisms of intervention with regard to gut microbiota in renal diseases.

KEYWORDS:

AKI; Acute kidney injury; dysbiosis; gut microbiota; intestinal microbiota

PMID:
30606403
PMCID:
PMC6322425
[Available on 2020-01-01]
DOI:
10.1016/j.semnephrol.2018.10.009

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