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Genome Biol. 2019 Jan 3;20(1):1. doi: 10.1186/s13059-018-1612-0.

The Network of Cancer Genes (NCG): a comprehensive catalogue of known and candidate cancer genes from cancer sequencing screens.

Author information

1
Cancer Systems Biology Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
2
School of Cancer and Pharmaceutical Sciences, King's College London, London, SE1 1UL, UK.
3
Cancer Systems Biology Laboratory, The Francis Crick Institute, London, NW1 1AT, UK. francesca.ciccarelli@crick.ac.uk.
4
School of Cancer and Pharmaceutical Sciences, King's College London, London, SE1 1UL, UK. francesca.ciccarelli@crick.ac.uk.

Abstract

The Network of Cancer Genes (NCG) is a manually curated repository of 2372 genes whose somatic modifications have known or predicted cancer driver roles. These genes were collected from 275 publications, including two sources of known cancer genes and 273 cancer sequencing screens of more than 100 cancer types from 34,905 cancer donors and multiple primary sites. This represents a more than 1.5-fold content increase compared to the previous version. NCG also annotates properties of cancer genes, such as duplicability, evolutionary origin, RNA and protein expression, miRNA and protein interactions, and protein function and essentiality. NCG is accessible at http://ncg.kcl.ac.uk/ .

KEYWORDS:

Cancer genes; Cancer genomics screens; Cancer heterogeneity; Systems-level properties

PMID:
30606230
PMCID:
PMC6317252
DOI:
10.1186/s13059-018-1612-0
[Indexed for MEDLINE]
Free PMC Article

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