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J Asian Nat Prod Res. 2019 Aug;21(8):754-771. doi: 10.1080/10286020.2018.1520704. Epub 2019 Jan 3.

Andrographolide is neither a human organic anion transporter 1 (hOAT1) substrate nor inhibitor.

Author information

1
a Malaysian Institute of Pharmaceuticals and Nutraceuticals, NIBM , Ministry of Science Technology and Innovation (MOSTI) , Pulau Pinang , Malaysia.
2
b Institute for Research in Molecular Medicine (INFORMM) , Universiti Sains Malaysia , Pulau Pinang , Malaysia.
3
c Advanced Medical and Dental Institute , Universiti Sains Malaysia , Pulau Pinang , Malaysia.

Abstract

Andrographolide, a major bioactive compound isolated from Andrographis paniculata (Burm. F.) Nees, was evaluated for its effects on the hOAT1 membrane transporter. Substrate determination and inhibition of hOAT1-mediated uptake transport assay was carried out using recombinant CHO-hOAT1 cells. The results showed that the uptake ratio of andrographolide was less than 2.0 at all concentrations tested, indicating that andrographolide is not a hOAT1 substrate. Andrographolide has no significant effects on the p-aminohippuric acid uptake and on the mRNA and protein expression of hOAT1. In conclusion, andrographolide may not pose a drug-herb interaction risk related to hOAT1.

KEYWORDS:

Andrographolide; drug–herb interaction; hOAT1; membrane transporter; toxicity

PMID:
30606060
DOI:
10.1080/10286020.2018.1520704
[Indexed for MEDLINE]

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