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New Microbiol. 2018 Oct;41(4):247-255.

Evidence-based renewal of the Italian guidelines for the use of antiretroviral agents and the diagnostic-clinical management of HIV-1 infected persons.

Author information

1
National Institute for Infectious Diseases L. Spallanzani, IRCCS, Rome, Italy.
2
Policlinico San Martino Hospital, IRCCS for Cancer Research Genova, Italy.
3
Nadir Onlus, Rome, Italy.
4
University of Tor Vergata, Rome, Italy.
5
University of Bari, Italy.
6
P.O. Cotugno, AORN Ospedali dei Colli, Naples, Italy.
7
San Paolo Hospital, University of Milan, Italy.
8
University of Turin, Italy.
9
University of Milan, Italy.
10
Division of Infectious Diseases, IRCCS Ospedale San Raffaele, Milan, Italy.
11
Policlinico Ca Granda Hospital, University of Milan; Italy.
12
University of Modena and Reggio Emilia, Modena, Italy.
13
University of Milan - ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
14
San Raffaele Scientific Institute, Milan, Italy.

Abstract

The Italian Society for Infectious and Tropical Diseases (SIMIT) in collaboration with the Technical Health Committee (Sections L and M) of the Italian Ministry of Health have supported the renewal of the recommendations for the Italian guidelines for the use of antiretroviral agents and the diagnostic-clinical management of HIV-1 infected persons. This publication summarizes the latest updates to the 2017 version of the Italian Guidelines for the management of HIV-1 infected patients and the use of antiretroviral drugs. New recommendations were released framing the clinical questions the use of antiretrovirals according to the Patient Intervention Comparator Outcome (PICO) methodology and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system. Diagnostic tools for immunological and virological monitoring, when to start, what to start, optimization and therapeutic failure were updated in order to include the recommendation obtained with these newly developed methods. For a complete review of clinical and therapeutic relevant topics we refer the reader to the extended version of the Guidelines.

KEYWORDS:

Antiretroviral therapy; HIV; Treatment guidelines

PMID:
30604833
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