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Indian J Cancer. 2018 Apr-Jun;55(2):134-137. doi: 10.4103/ijc.IJC_418_17.

Primary cutaneous B-cell lymphoma: A single-center 5-year experience.

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1
Department of Medical Oncology, Kidwai Cancer Institute, Bengaluru, Karnataka, India.

Abstract

BACKGROUND:

Skin is the second most common site for extranodal non-Hodgkin's lymphoma (NHL). Most primary cutaneous NHLs are of T-cell origin (70%). Primary cutaneous B-cell lymphoma (PCBCL) is a rare entity.

MATERIALS AND METHODS:

Patients diagnosed with PCBCL between January 2012 and July 2017 at our center were retrospectively analyzed.

RESULTS:

Eight patients of PCBCL were diagnosed. Three patients (37.5%) were males while 5 patients (62.5%) were females. The median age at diagnosis was 45 years (range, 18-60 years). Scalp was the most common site of involvement (50% of the patients). Diffuse large B-cell lymphoma (DLBCL) was the most common histology (63%), with leg-type DLBCL diagnosed in 1 patient. Two patients had primary cutaneous follicle center lymphoma, whereas the remaining 1 patient had precursor B-lymphoblastic lymphoma. All 5 DLBCL cases were treated with CHOP chemotherapy, and rituximab was given to 3 patients. Of the primary cutaneous follicle center lymphomas, 1 patient with stage II disease was treated with CHOP and is alive without recurrence for the past 5 years, whereas the other patient is on observation alone. The patient with precursor B-lymphoblastic lymphoma was started on MCP-841 protocol; however, the patient did not complete the treatment and died after 11 months.

CONCLUSIONS:

PCBCL is a heterogeneous group of diseases and dividing them into subtypes, based on morphology and immunophenotype, has therapeutic implications.

KEYWORDS:

Cutaneous B-cell lymphoma; cutaneous diffuse large B-cell lymphoma; cutaneous lymphoma prognosis; skin lymphoma

PMID:
30604723
DOI:
10.4103/ijc.IJC_418_17
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