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Lung India. 2019 Jan-Feb;36(1):60-62. doi: 10.4103/lungindia.lungindia_21_18.

Cavitary lung disease following transbronchial biopsy using cryoadhesion in a patient with diffuse parenchymal lung disease.

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Division of Pulmonary and Critical Care Medicine, Wakemed Health and Hospitals, Raleigh, North Carolina, USA.
Department of Medicine, Campbell University School of Osteopathic Medicine, Lillington, North Carolina, USA.


Transbronchial lung biopsy using cryoadhesion is a diagnostic technique gaining in popularity. Several studies have been performed on its diagnostic yield and safety profile. However, definitive conclusions are limited due to the heterogeneity of results. The most common complications described in the current literature are pneumothorax and hemorrhage. This case describes a 60-year-old female who developed a cavitary lung lesion shortly after undergoing transbronchial lung cryobiopsy, highlighting the need for further research on the rarer complications that may be associated with this promising procedure.


Cryoadhesion; cryobiopsy; diffuse parenchymal lung disease; interstitial lung disease; transbronchial biopsy

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