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J Mol Neurosci. 2019 Jan 2. doi: 10.1007/s12031-018-1239-3. [Epub ahead of print]

GM1 Acupoint Injection Improves Mental Retardation in Children with Cerebral Palsy.

Author information

1
Department of Children Rehabilitation Medicine, Fifth Affiliated Hospital of Zhengzhou University, No. 3 rehabilitation Street, 27 District, Zhengzhou, 450052, Henan, China. 13526676676@126.com.
2
Department of Children Rehabilitation Medicine, Fifth Affiliated Hospital of Zhengzhou University, No. 3 rehabilitation Street, 27 District, Zhengzhou, 450052, Henan, China.
3
Laboratory, Henan Province Hospital of Traditional China Medicine, Zhengzhou, 450052, Henan, China.
4
Department of Children Rehabilitation Medicine, Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.

Abstract

To study the clinical effectiveness and mechanism of GM1 acupoint injection therapy on mental retardation for children with cerebral palsy (CP). A total of 90 children with CP were divided into acupoint injection group (group A), subcutaneous injection group (group B), and control group (group C). Another 30 healthy children were set as a healthy control group (group D). The Mental Developmental Index (MDI), Psychomotor Developmental Index (PDI), and hemodynamic parameters in the cerebral arteries were measured before and after treatment. After three treatment courses, the MDI and PDI in groups A, B, and C were increased, and the increase in group A was most obvious (P < 0.05). Peak systolic velocity, mean velocity, and end-diastolic velocity were also elevated in group A, and after three treatment courses, resistance index decreased with a statistical significance (P < 0.05). However, there were no significant changes in groups B and C (P > 0.05). For all groups, neuron-specific enolase levels decreased and total superoxide dismutase increased after treatment. Acupoint injection therapy combined with conventional rehabilitation therapy demonstrated significant effects on cerebral hemodynamic conditions for children with CP.

KEYWORDS:

Acupoint injection; Cerebral blood flow; Cerebral palsy; Mental retardation; Rehabilitation therapy

PMID:
30604381
DOI:
10.1007/s12031-018-1239-3

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