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Psychopharmacology (Berl). 2019 Feb;236(2):731-740. doi: 10.1007/s00213-018-5106-2. Epub 2019 Jan 2.

Microdosing psychedelics: personality, mental health, and creativity differences in microdosers.

Author information

1
Department of Psychology, University of Toronto, Toronto, ON, Canada. metathomas.anderson@mail.utoronto.ca.
2
Department of Psychology, York University, Toronto, ON, Canada. rotem@boredomlab.org.
3
Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
4
Centre for Addiction and Mental Health, Toronto, ON, Canada.
5
Department of Psychology, University of Toronto Scarborough, Scarborough, ON, Canada.
6
Department of Psychology, University of Toronto, Toronto, ON, Canada.

Abstract

RATIONALE:

Microdosing psychedelics-the regular consumption of small amounts of psychedelic substances such as LSD or psilocybin-is a growing trend in popular culture. Recent studies on full-dose psychedelic psychotherapy reveal promising benefits for mental well-being, especially for depression and end-of-life anxiety. While full-dose therapies include perception-distorting properties, microdosing mayprovide complementary clinical benefits using lower-risk, non-hallucinogenic doses.

OBJECTIVES:

This pre-registered study aimed to investigate whether microdosing psychedelics is related to differences in personality, mental health, and creativity.

METHODS:

In this observational study, respondents recruited from online forums self-reported their microdosing behaviors and completed questionnaires concerning dysfunctional attitudes, wisdom, negative emotionality, open-mindedness, and mood. Respondents also performed the Unusual Uses Task to assess their creativity.

RESULTS:

Current and former microdosers scored lower on measures of dysfunctional attitudes (p < 0.001, r = - 0.92) and negative emotionality (p = 0.009, r = - 0.85) and higher on wisdom (p < 0.001, r = 0.88), openmindedness(p = 0.027, r = 0.67), and creativity (p < 0.001, r = 0.15) when compared to non-microdosing controls.

CONCLUSIONS:

These findings provide promising initial evidence that warrants controlled experimental research to directly test safety and clinical efficacy. As microdoses are easier to administer than full-doses, this new paradigm has the exciting potential to shape future psychedelic research.

KEYWORDS:

Creativity; Dysfunctional Attitudes; LSD; Microdosing; Negative Emotionality; Open Mindedness; Preregistered; Psilocybin; Psychedelic; Wisdom

PMID:
30604183
DOI:
10.1007/s00213-018-5106-2
[Indexed for MEDLINE]

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