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Eur J Immunol. 1988 Nov;18(11):1847-50.

Transcription of protooncogenes during stimulation of normal human B lymphocytes.

Author information

1
Department of Pathology, Norwegian Radium Hospital, Oslo, Norway.

Abstract

Protooncogenes play important roles in the regulation of growth and differentiation of normal cells. In this study we have examined the cell cycle-dependent regulation of transcription of various protooncogenes after stimulation of human peripheral blood B lymphocytes. The transcriptional rate of various genes was determined by means of a nuclear run-on assay. We found that several protooncogenes were transcriptionally activated after stimulation (myc, p53, K-ras, H-ras, sis and ets), but with different kinetics of induction. In contrast, some oncogenes, especially those encoding membrane-associated or cytoplasmatic proteins like abl, rel or mil/raf, were transcribed at a relatively constant rate during the cell cycle.

PMID:
3060364
DOI:
10.1002/eji.1830181131
[Indexed for MEDLINE]

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