Format

Send to

Choose Destination
Nat Cell Biol. 2019 Jan;21(1):25-31. doi: 10.1038/s41556-018-0234-9. Epub 2019 Jan 2.

Integrin activation by talin, kindlin and mechanical forces.

Author information

1
Max Planck Institute of Biochemistry, Martinsried, Germany. zsun@biochem.mpg.de.
2
University of Valencia, Valencia, Spain. mercedes.costell@uv.es.
3
Max Planck Institute of Biochemistry, Martinsried, Germany. faessler@biochem.mpg.de.

Abstract

Integrins are the major family of adhesion molecules that mediate cell adhesion to the extracellular matrix. They are essential for embryonic development and influence numerous diseases, including inflammation, cancer cell invasion and metastasis. In this Perspective, we discuss the current understanding of how talin, kindlin and mechanical forces regulate integrin affinity and avidity, and how integrin inactivators function in this framework.

PMID:
30602766
DOI:
10.1038/s41556-018-0234-9
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center